Nurse John: Against Medical Advice Tour LIVE at Old National Centre

About the Performer

Nurse John is one of the fastest-rising stars in stand-up comedy, known for his infectious energy, relatable storytelling, and hilarious takes on everyday life. With a background in healthcare that gives him a uniquely human perspective, Nurse John has built a massive following through his viral social media content and sold-out live shows across the country.

His comedy blends personal anecdotes, observational humor, and sharp wit that resonates with audiences of all backgrounds. Whether he's riffing on relationships, work life, or the absurdities of modern society, Nurse John delivers laughs with authenticity and heart. His "Against Medical Advice Tour" is his biggest and most ambitious tour to date, bringing his headline act to major venues nationwide.

With millions of fans online and a rapidly growing live audience, Nurse John is cementing his place as one of the most exciting voices in comedy today. Don't miss your chance to see him live in Indianapolis!

Event Details

Date: Thursday, October 22, 2026

Show Time: 7:00 PM EDT

Venue: Old National Centre (Egyptian Room), 502 N. New Jersey St., Indianapolis, IN 46204

Doors Open: Approximately 6:00 PM

Age Restrictions: All ages welcome. Content may include mature themes.

Ticket Prices: Starting from $37

About the Venue

Old National Centre is one of Indianapolis's premier entertainment destinations, located at 502 N. New Jersey Street in the heart of downtown. The venue is home to multiple performance spaces, including the iconic Egyptian Room — a stunning ballroom with Egyptian Revival architecture, soaring ceilings, and a capacity of approximately 1,800 guests.

The Egyptian Room features a flexible general admission layout that creates an electric, up-close atmosphere for comedy shows. The venue's punchy acoustics and tight sightlines ensure every seat delivers an excellent view of the stage. Multiple bars, quick-moving entry points, and a dedicated merch area keep the experience smooth from start to finish.

Located steps from Mass Ave dining and entertainment, Old National Centre is easily accessible via rideshare and public transit. Nearby parking garages are available for those driving. The venue is known for its lively crowd and top-notch production quality, making it one of the best places in Indianapolis to catch a live comedy show.

What to Expect

Nurse John's "Against Medical Advice Tour" is a full headline stand-up comedy show featuring his best material and brand-new jokes developed specifically for this tour. Expect a high-energy, laugh-out-loud performance that runs approximately 90 minutes to two hours.

The show will feature Nurse John's signature blend of personal storytelling, observational comedy, and crowd interaction. His ability to connect with audiences in real time makes every show feel unique and spontaneous. Fans who have followed him online will recognize his style, but the live experience takes it to a whole new level.

This is a must-see show for comedy fans in Indianapolis. Arrive early to grab a drink, find your spot, and get ready for a night of non-stop laughs with one of comedy's hottest rising stars.

Ticket Information

Ticket Price Range: Starting from $37 (official) | Resale from $37 via VividSeats

Official tickets are available through Ticketmaster. Resale tickets are available through VividSeats with a 100% Buyer Guarantee.

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